Greer started working in a number of commercials. Greer has appeared in a recurring role on the Fox television series, Arrested Development, playing George Bluth, Sr.'s (Jeffrey Tambor) former secretary Kitty Sanchez. Her film credits include Kissing a Fool, Jawbreaker, Adaptation., The Village, 13 Going on 30, 27 Dresses, The Grand and Jurassic World. Greer starred in the 2008 ABC sitcom, Miss Guided, but the sitcom was canceled shortly after it aired. In April 2008 Greer appeared as a yoga instructor in the "Get a Mac" ad series alongside John Hodgman and Justin Long.