As of December 22, 2010, Two and a Half Men is ranked at #10 on the 10 most watched TV programs of 2010. This was Charlie Sheen's final season of Two and a Half Men before his firing on March 7, 2011.
- Charlie Sheen as Charlie Harper (16 episodes)
- Jon Cryer as Alan Harper (16 episodes)
- Angus T. Jones as Jake Harper (15 episodes)
- Marin Hinkle as Judith Harper-Melnick (7 episodes)
- Conchata Ferrell as Berta (14 episodes)
- and Holland Taylor as Evelyn Harper (6 episodes)
- Courtney Thorne-Smith as Lyndsey McElroy (8 episodes)
- Graham Patrick Martin as Eldridge McElroy (7 episodes)
- Ryan Stiles as Herb Melnick (5 episodes)
- Kelly Stables as Melissa (2 episodes)
- Judd Nelson as Chris McElroy (2 episodes)
- J. D. Walsh as Gordon (2 episodes)
- Liz Vassey as Michelle (2 episodes)
- Melanie Lynskey as Rose (4 episodes)
- A Mannequin as Manny Quinn (4 episodes)
|Image||Title||Original Airdate||#||Summary||Title Quotation From|
|Three Girls and a Guy Named Bud||September 20, 2010||801||When Jake finds out that Alan has been dating Eldridge's mom, he packs up and heads to Judith and Herb's. Meanwhile, Charlie decides it's time to cut back on boozing.||Charlie|
|A Bottle of Wine and a Jackhammer||September 27, 2010||802||When Lyndsey wants Alan to move in with her, Charlie goes to great lengths to get his brother to do just that.||Charlie|
|A Pudding-Filled Cactus||October 4, 2010||803||Alan moves in with Lyndsey, but continues to have a rendezvous with Melissa at Charlie's house.||Alan|
|Hookers, Hookers, Hookers||October 11, 2010||804||Lyndsey and Eldridge move into Charlie's house after Alan burns down their home.||Charlie|
|The Immortal Mr. Billy Joel||October 18, 2010||805||Alan goes out on the town pretending to be Charlie, while Charlie sneaks off for some cosmetic surgery.||Alan|
|Twanging Your Magic Clanger||October 25, 2010||806||Charlie has trouble adjusting to dating a slightly older woman.||Charlie|
|The Crazy Bitch Gazette||November 1, 2010||807||Charlie's past comes back to bite him when his girlfriend decides that his stalker, Rose, is just too much to handle.||Charlie|
|Springtime on a Stick||November 8, 2010||808||Charlie and Alan try to set up their mother, Evelyn, on a date with Russell, the pharmacist.||Russle|
|A Good Time in Central Africa||November 15, 2010||809||When Berta takes a couple days off work, Charlie begins to fall for her replacement; while Alan believes he is being stalked by Lyndsey's ex-husband, Chris.||Charlie|
|Ow, Ow, Don't Stop||November 22, 2010||810||Charlie goes on a spending spree for his old fling, Courtney, who shows up after three years in prison for conning him out of money.||Charlie|
|Dead from the Waist Down||December 6, 2010||811||Alan is ashamed that he can't afford to buy a nice birthday present to Lyndsey, so he gets creative.||Alan|
|Chocolate Diddlers or My Puppy's Dead||December 13, 2010||812||Charlie gets depressed after he and Courtney break-up and go to see his psychiatrist, Dr. Freeman.||Charlie and Alan|
|Skunk, Dog, Crap and Ketchup||January 3, 2011||813||When Charlie and Lyndsey start becoming friendly, Alan's paranoia gets the best of him.||Alan|
|Lookin' for Japanese Subs||January 17, 2011||814||
Charlie's obsession with the newly "married" Rose leads him to stalk her. Meanwhile, Alan grows concerned when Jake and Eldridge start videotaping stupid and extremely dangerous stunts.
|Three Hookers and a Philly Cheesesteak||February 7, 2011||815||Alan's chiropractic business turns into a Ponzi scheme, and Charlie and Rose carry on seeing each other.||Charlie|
|That Darn Priest||February 14, 2011||816||
Alan meets Rose's "husband" after she uncovers his Ponzi scheme.
- This is one of the only seasons not to end in May. The only other being the 12th and final season.
- This season marks the final appearance of Charlie Sheen as Charlie Harper. Charlie has since been portrayed by Kathy Bates in several of Alan's dreams in "Why We Gave Up Women", as well as a body-double (only seen from the back) in "Of Course He's Dead".